Background and aim: Our study was aimed to compare multiphasic multi-detector computed tomography after secretin stimulation and mangafodipir trisodium-enhanced magnetic resonance imaging plus MR cholangiopancreatography in the characterization of solid pancreatic lesions. Patients and methods: Forty patients with ultrasound diagnosis of solid pancreatic lesion prospectively underwent both multi-detector computed tomography and magnetic resonance imaging. Three minutes after intravenous administration of secretin, post-contrast computed tomography scans were performed 40, 80, and 180s after contrast medium injection. MR protocol included axial/coronal, thin/thick-slab, single-shot T2w sequences and axial/coronal T1w breath-hold spoiled gradient-echo images before and 30-40 min after intravenous infusion of manganese clipyri-doxal diphosphate. Different observers blindly evaluated the ability of computed tomography and magnetic resonance imaging to characterize focal pancreatic lesions. Surgery, biopsy, and/or follow-up were considered as our diagnostic gold standard. Results: Thirty-five focal pancreatic lesions (adenocarcinoma, n = 18; focal chronic pancreatitis, It = 4; endocrine tumor, n = 6; metastasis, n = 1; cystic tumor, n = 3; indeterminate cystic lesions, n = 3) were present in 34 patients since the remaining 6 subjects showed no pathological finding. Both multi-detector computed tomography and magnetic resonance imaging showed a statistically significant correlation with the gold standard and between themselves in the characterization of 29 solid lesions of the pancreas (p<0.05). Conclusion: Both imaging techniques well correlate to final diagnosis of non-metastatic solid pancreatic lesions and particularly of adenocarcinomas with a slight advantage for mangafodipir trisodiumenhanced magnetic resonance imaging plus MR cholangiopancreatography. (C) 2009 Editrice Gastroenterologica Italiana S.r.I. Published by Elsevier Ltd. All rights reserved.
|Autori:||BORASCHI P; DONATI F; GIGONI R; SALEMI S; FAGGIONI L; DEL CHIARO M; BOGGI U; BARTOLOZZI C; FALASCHI F|
|Titolo:||Secretin-stimulated multi-detector CT versus mangafodipir trisodium-enhanced MR imaging plus MRCP in characterization of non-metastatic solid pancreatic lesions|
|Anno del prodotto:||2009|
|Digital Object Identifier (DOI):||10.1016/j.dld.2009.02.005|
|Appare nelle tipologie:||1.1 Articolo in rivista|