Background: Arterial stiffness (AS) reflects morfo-functional modifications of elastic arteries due to aging and atherosclerosis. Carotid-femoral pulse wave velocity (PWVcf) represents an estabilished marker of aortic stiffness and predictor of cardiovascular mortality. Recently, a new method for evaluating arterial stiffness based on brachial-ankle pulse wave velocity (PWVba) and capable to provide a stiffness index, CAVI (cardio-ankle vascular index), has been proposed. Aim: to compare PWVba with PWVcf and to evaluate the corresponding relationships with age and blood pressure in healthy subjects and patients with major risk factors for atherosclerosis. Methods: 46 subjects (19 controls; 27 patients with risk factors but without clinical cardiovascular disease; 31 women; age 43±18) were studied. PWVcf was assessed by the estabilished foot to foot method (Complior Artech, Paris); PWVba and CAVI were obtained by a commercially available system (Vasera Fukuda, Tokyo), recording simultaneously brachial and tibial sphygmogram, ECG and phonocardiogram (PGC). CAVI is derived from the stiffness index Beta, according to Bramwell-Hill formula. Results: PWba was significantly correlated with PWVcf (r 0.785, p
Brachial-ankle pulse wave velocity: a new method for clinical evaluation of arterial stiffness compared with carotid-femoral pulse wave velocity
PALOMBO, CARLO;DI STEFANO, ROSSELLA;BALBARINI, ALBERTO
2008-01-01
Abstract
Background: Arterial stiffness (AS) reflects morfo-functional modifications of elastic arteries due to aging and atherosclerosis. Carotid-femoral pulse wave velocity (PWVcf) represents an estabilished marker of aortic stiffness and predictor of cardiovascular mortality. Recently, a new method for evaluating arterial stiffness based on brachial-ankle pulse wave velocity (PWVba) and capable to provide a stiffness index, CAVI (cardio-ankle vascular index), has been proposed. Aim: to compare PWVba with PWVcf and to evaluate the corresponding relationships with age and blood pressure in healthy subjects and patients with major risk factors for atherosclerosis. Methods: 46 subjects (19 controls; 27 patients with risk factors but without clinical cardiovascular disease; 31 women; age 43±18) were studied. PWVcf was assessed by the estabilished foot to foot method (Complior Artech, Paris); PWVba and CAVI were obtained by a commercially available system (Vasera Fukuda, Tokyo), recording simultaneously brachial and tibial sphygmogram, ECG and phonocardiogram (PGC). CAVI is derived from the stiffness index Beta, according to Bramwell-Hill formula. Results: PWba was significantly correlated with PWVcf (r 0.785, pI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
