Density, affinity, and subtype distribution of endothelin-1 (ET-1) binding sites were determined in rat cardiac tissue as a function of age in order to evaluate the association of alterations in the endothelin receptor system and aging in the heart. A significant decrease in the receptor subtype ET-A, which represents 70% to 80% of the total receptor population in cardiac tissue of 3- and 12-month-old rats, was observed in 24-month-old rats with respect to the younger groups. These findings indicate an alteration in ET-1 cardiac receptors associated with aging, mainly due to a variation in the receptor subtype distribution.
|Autori:||DEL RY S; MALTINTI M; GIANNESSI D; CAVALLINI G; BERGAMINI E|
|Titolo:||Age-related changes in endothelin-1 receptor subtypes in rat heart|
|Anno del prodotto:||2008|
|Appare nelle tipologie:||1.1 Articolo in rivista|