Invasive lobular carcinoma (ILC) represents 15% of invasive human breast tumours. This report describes the morphological and immunohistochemical features of three canine mammary tumours comparable with human ILC. These tumours were composed of a non-delimited proliferation of discrete cells infiltrating fibrous connective tissue. Multifocal in-situ carcinoma associated with invasive lesions was present. Invasive tumour cells and in-situ lesions expressed cytokeratin and CK34betaE12, but not E-cadherin. Based on these morphological and immunohistochemical characteristics, the tumours were classified as canine ILC. (C) 2010 Elsevier Ltd. All rights reserved.
|Autori:||Ressel L; Millanta F; Poli A|
|Titolo:||Canine Invasive Lobular Carcinoma of the Mammary Gland: Morphological and Immunohistochemical Characterizations of Three Cases|
|Anno del prodotto:||2011|
|Digital Object Identifier (DOI):||10.1016/j.jcpa.2010.08.015|
|Appare nelle tipologie:||1.1 Articolo in rivista|