Combinations of partial esters of alternating maleic anhydride/mono-methoxyoligoethyleneglycol vinyl ethers copolymers with human serum albumin have been found suitable to give transparent, flexible and coherent films that display a marked hydrogel character and safely pass preliminary "in vitro" and "in vivo" toxicity tests. They have been used in the fabrication of polymeric inserts containing alpha-interferon (IFN(alpha)) by a low temperature casting procedure. Water uptake, dissolution levels, and kinetic release profiles of the active principle from inserts are presented and analyzed in terms of the different extent of hydrophilic interactions of proteins with the synthetic component in the hybrid polymer matrices.
|Autori interni:||CHIELLINI, EMO|
|Autori:||Chiellini E; Solaro R; Leonardi G; Giannasi D; Lisciani R; Mazzanti G|
|Titolo:||New polymeric hydrogel formulations for the controlled release of protein drugs|
|Anno del prodotto:||1992|
|Digital Object Identifier (DOI):||10.1016/0168-3659(92)90102-W|
|Appare nelle tipologie:||1.1 Articolo in rivista|