The synthesis of several N-(indol-3-ylglyoxylyl)dopamine derivatives is described. The target compounds were prepared starting from substituted indoleglyoxylyl chlorides and dopamine hydrochloride. An analogous compound derived from 2-aminobenzimidazole is reported. All the products were tested for their anti-depressant activity. The N-(5-chloroindol-3-ylglyoxylyl)dopamine 3c proved to be of particular interest and exhibited a good activity in all the tests performed.
|Autori:||G. Primofiore; Marini A; F. Da Settimo; J.S. Franzone; U. Mason; C. Reboani; R. Cirillo.|
|Titolo:||N-(Indol-3-ylglyoxylyl)dopamine derivatives: preparation and antidepressant activity|
|Anno del prodotto:||1988|
|Digital Object Identifier (DOI):||10.1016/0223-5234(88)90216-4|
|Appare nelle tipologie:||1.1 Articolo in rivista|