The effects of a chronic administration of suramin were evaluated on renal parenchyma of young rats. Animals were given suramin 18 mg/kg i.p. twice a week for two months, a treatment schedule equivalent to that used in cancer patients. At the end of the treatment, suramin concentrations in plasma and kidney were assayed and a morphohistochemical examination of renal parenchyma was carried out. Marked and widespread alterations were detected in both cortex and medulla and were associated with elevated tissue suramin levels exceeding 5 mg/g of tissue. The present data demonstrate that suramin induces a severe chronic renal damage in the rat, associated with high drug tissue levels.
|Autori:||Soldani P; Danesi R; Ricciardi M P; Pellegrini A; Natale G; Paparelli A.|
|Titolo:||Morphohistochemical characterization of suramin--induced chronic toxicity in rat kidney.|
|Anno del prodotto:||1992|
|Appare nelle tipologie:||1.1 Articolo in rivista|