The effects of a chronic administration of suramin were evaluated on renal parenchyma of young rats. Animals were given suramin 18 mg/kg i.p. twice a week for two months, a treatment schedule equivalent to that used in cancer patients. At the end of the treatment, suramin concentrations in plasma and kidney were assayed and a morphohistochemical examination of renal parenchyma was carried out. Marked and widespread alterations were detected in both cortex and medulla and were associated with elevated tissue suramin levels exceeding 5 mg/g of tissue. The present data demonstrate that suramin induces a severe chronic renal damage in the rat, associated with high drug tissue levels.

Morphohistochemical characterization of suramin--induced chronic toxicity in rat kidney.

SOLDANI, PAOLA;DANESI, ROMANO;RICCIARDI, MARIA PAOLA;NATALE, GIANFRANCO;
1992-01-01

Abstract

The effects of a chronic administration of suramin were evaluated on renal parenchyma of young rats. Animals were given suramin 18 mg/kg i.p. twice a week for two months, a treatment schedule equivalent to that used in cancer patients. At the end of the treatment, suramin concentrations in plasma and kidney were assayed and a morphohistochemical examination of renal parenchyma was carried out. Marked and widespread alterations were detected in both cortex and medulla and were associated with elevated tissue suramin levels exceeding 5 mg/g of tissue. The present data demonstrate that suramin induces a severe chronic renal damage in the rat, associated with high drug tissue levels.
1992
Soldani, Paola; Danesi, Romano; Ricciardi, MARIA PAOLA; Pellegrini, A; Natale, Gianfranco; Paparelli, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/198287
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