In the present study, we examined the effect of metadoxine on striatal levels of dopamine, 5-hydroxytryptamine (5-HT) and their metabolites in male C57 Black mice. Striatal content was assayed after systemic administration of metadoxine ranging from 1 micrograms kg-1 to 500 mg kg-1. Striatal dopamine increased 1 h after treatment with metadoxine (150 mg kg-1), but the most notable effect was obtained 24 h after the drug administration. At this time a plateau was reached; the two major metabolites of dopamine showed the same trend. Seven days after metadoxine administration, striatal dopamine approached the control values. Over the same time intervals, striatal 5-HT increased to a lesser extent and 5-hydroxy-indoleacetic acid did not differ significantly from controls. Striatal dopamine increased significantly at a dose of 250 micrograms kg-1 up to a dose of 1 mg kg-1 metadoxine; no further increment was observed between 1 and 500 mg kg-1 metadoxine. Administration of each component at doses equimolar to 1 mg metadoxine showed that pyridoxine produced only a mild increase in striatal dopamine compared with controls. We suggest that the metadoxine-induced striatal dopamine increase is obtained by increasing synthesis of dopamine.
|Autori interni:||FORNAI, FRANCESCO|
CORSINI, GIOVANNI UMBERTO
|Autori:||FORNAI F; ALESSANDRI MG; BONUCCELLI U; SCALORI V; CORSINI GU.|
|Titolo:||Effect of metadoxine on striatal dopamine levels in C57 black mice|
|Anno del prodotto:||1993|
|Digital Object Identifier (DOI):||10.1111/j.2042-7158.1993.tb05579.x|
|Appare nelle tipologie:||1.1 Articolo in rivista|