1. Hirunorms are new synthetic peptides designed to interact with thrombin in a similar way to the natural inhibitor hirudin. 2. Hirunorms are specific and efficient in vitro inhibitors of thrombin activity. 3. Hirunorms are potent anticoagulant and antithrombotic agents in in vivo experimental models devoid of hemorrhagic effects at doses that are active in preventing thrombosis. (C) 1998 Elsevier Science Inc.

Hirunorms, novel hirudin-like direct thrombin inhibitors

CAPPIELLO, MARIO;DEL CORSO, ANTONELLA;MURA, UMBERTO
1998

Abstract

1. Hirunorms are new synthetic peptides designed to interact with thrombin in a similar way to the natural inhibitor hirudin. 2. Hirunorms are specific and efficient in vitro inhibitors of thrombin activity. 3. Hirunorms are potent anticoagulant and antithrombotic agents in in vivo experimental models devoid of hemorrhagic effects at doses that are active in preventing thrombosis. (C) 1998 Elsevier Science Inc.
Cappiello, Mario; Vilardo, Pg; DEL CORSO, Antonella; Mura, Umberto
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/198548
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