Background: Cohort studies have demonstrated an association between C-reactive protein (CRP) and interleukin-6 (IL- 6) and all-cause and cardiovascular mortality in end-stage renal disease (ESRD) patients. Interleukin-8 ( IL-8) appears to be not only the plasma expression of the acute-phase response but also a direct pathogenetic mediator of the atherosclerotic process. Methods: To evaluate the role of IL-8 in predicting outcome, 76 chronic dialytic patients were prospectively followed for 18 months. At baseline, blood samples were taken for analysis of high-sensitivity CRP, IL- 6, IL- 8 and other standard laboratory analyses. Results: Median IL- 8 was 5.2 mg/l, therefore near half of the patients had IL-8 values within the range of 'normal limits'. IL-6 and CRP were significantly correlated (r = 0.45, p < 0.001) and a positive correlation was also found between IL-6 and IL-8 (r = 0.39, p < 0.001). The correlation coefficient between IL- 6 and CRP was 0.43 (p < 0.001) and 0.50 (p < 0.001) in patients without and with history and/ or clinical signs of cardiovascular disease, respectively. After a follow-up of 1.5 years, 8 patients had died from cardiovascular causes and another 7 patients for other reasons; furthermore 9 major nonfatal cardiovascular events were recorded. Stepwise regression analysis showed IL-8 as the strongest independent predictor of all-cause and cardiovascular events (p = 0.0025) even after adjustment for age and dialytic age, followed by IL- 6 and CRP (p < 0.01). Conclusion: Despite a small population and a relatively short follow- up period, this study firstly demonstrated that IL-8 is a powerful independent predictive factor for cardiovascular and overall mortality cause in ESRD patients.

Interleukin-8 is a powerful prognostic predictor of all-cause and cardiovascular mortality in dialytic patients

PANICHI, VINCENZO;GHIADONI, LORENZO;CRISTOFANI, RENZA;
2006

Abstract

Background: Cohort studies have demonstrated an association between C-reactive protein (CRP) and interleukin-6 (IL- 6) and all-cause and cardiovascular mortality in end-stage renal disease (ESRD) patients. Interleukin-8 ( IL-8) appears to be not only the plasma expression of the acute-phase response but also a direct pathogenetic mediator of the atherosclerotic process. Methods: To evaluate the role of IL-8 in predicting outcome, 76 chronic dialytic patients were prospectively followed for 18 months. At baseline, blood samples were taken for analysis of high-sensitivity CRP, IL- 6, IL- 8 and other standard laboratory analyses. Results: Median IL- 8 was 5.2 mg/l, therefore near half of the patients had IL-8 values within the range of 'normal limits'. IL-6 and CRP were significantly correlated (r = 0.45, p < 0.001) and a positive correlation was also found between IL-6 and IL-8 (r = 0.39, p < 0.001). The correlation coefficient between IL- 6 and CRP was 0.43 (p < 0.001) and 0.50 (p < 0.001) in patients without and with history and/ or clinical signs of cardiovascular disease, respectively. After a follow-up of 1.5 years, 8 patients had died from cardiovascular causes and another 7 patients for other reasons; furthermore 9 major nonfatal cardiovascular events were recorded. Stepwise regression analysis showed IL-8 as the strongest independent predictor of all-cause and cardiovascular events (p = 0.0025) even after adjustment for age and dialytic age, followed by IL- 6 and CRP (p < 0.01). Conclusion: Despite a small population and a relatively short follow- up period, this study firstly demonstrated that IL-8 is a powerful independent predictive factor for cardiovascular and overall mortality cause in ESRD patients.
Panichi, Vincenzo; Taccola, D; Rizza, Gm; Consani, C; Ghiadoni, Lorenzo; Filippi, C; Cristofani, Renza; Panicucci, E; Migliori, M; Sidoti, A; Biagioli, M; Boracelli, D; Barsotti, G; Tetta, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/199086
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