We reported evidence of abnormal oxidative stress in families of type 1 diabetics (T1DM). Our purposes were to compare the responses to exercise testing in controls and T1DM families, and their relationship with traditional and non cardiovascular risk factors. We studied 38 T1DM patients (age 37±12 y), 76 first-degree relatives (50±13 y), and 95 healthy subjects (44±13 y) without established coronary heart disease who underwent routine clinical cycle ergometer test. Measurements included medical history, ETT, cardiovascular risk assessment (body weight, blood pressure, cigarette smoking, physical activity, fasting plasma glucose and insulin, HbA1c, plasma lipids, C-reactive protein, fibrinogen, folate, homocysteine, and plasma thiols as biomarkers of protein oxidation). No patient presented exercise-induced angina. T1DM patients achieved a higher maximal exercise systolic blood pressure (SBP 191±30 vs 176±24 mmHg, p<0.05). SBP remained high at 2 and 4 minutes into recovery. An attenuated heart rate response to exercise, a measure of chronotropic incompetence (82±9 vs 89±9%, p<0.01), was observed. Relatives showed higher SBP at peak exercise (197±27 vs 187±30, p<0.05). In T1DM subjects, exercise-induced increase in SBP relative to maximum exercise capacity (∆ExSBP/W) was positively associated only with disease duration (p<0.001). In relatives and controls, ∆ExSBP/W correlated (p<0.001) positively with plasma total cholesterol and insulin resistance estimated by homeostasis model assessment, negatively with plasma thiols and regular exercise. An abnormal blood pressure response has been identified not only in type 1 diabetic probands, but also in asymptomatic normotensive non-diabetic relatives, in which it was associated with indices of insulin resistance and oxidative damage.

Systolic blood pressure response after exercise in type 1 diabetes families

MATTEUCCI, ELENA;GIAMPIETRO, OTTAVIO
2004

Abstract

We reported evidence of abnormal oxidative stress in families of type 1 diabetics (T1DM). Our purposes were to compare the responses to exercise testing in controls and T1DM families, and their relationship with traditional and non cardiovascular risk factors. We studied 38 T1DM patients (age 37±12 y), 76 first-degree relatives (50±13 y), and 95 healthy subjects (44±13 y) without established coronary heart disease who underwent routine clinical cycle ergometer test. Measurements included medical history, ETT, cardiovascular risk assessment (body weight, blood pressure, cigarette smoking, physical activity, fasting plasma glucose and insulin, HbA1c, plasma lipids, C-reactive protein, fibrinogen, folate, homocysteine, and plasma thiols as biomarkers of protein oxidation). No patient presented exercise-induced angina. T1DM patients achieved a higher maximal exercise systolic blood pressure (SBP 191±30 vs 176±24 mmHg, p<0.05). SBP remained high at 2 and 4 minutes into recovery. An attenuated heart rate response to exercise, a measure of chronotropic incompetence (82±9 vs 89±9%, p<0.01), was observed. Relatives showed higher SBP at peak exercise (197±27 vs 187±30, p<0.05). In T1DM subjects, exercise-induced increase in SBP relative to maximum exercise capacity (∆ExSBP/W) was positively associated only with disease duration (p<0.001). In relatives and controls, ∆ExSBP/W correlated (p<0.001) positively with plasma total cholesterol and insulin resistance estimated by homeostasis model assessment, negatively with plasma thiols and regular exercise. An abnormal blood pressure response has been identified not only in type 1 diabetic probands, but also in asymptomatic normotensive non-diabetic relatives, in which it was associated with indices of insulin resistance and oxidative damage.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/199099
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