Background and Aims: High blood cholesterol is a major modifiable risk factor for cardiovascular disease. Point-of-care lipid screening requires precise, accurate, and reliable instruments. The aim of this study was to evaluate the accuracy of the CardioChek PA analyzer in comparison with clinical diagnostic laboratory methods. Methods: In 50 diabetic patients, total cholesterol (TC) was measured by using PTS PANELS CHOL+GLU Test Panel test strips and venous blood drawn in EDTA; in additional 18 patients, TC, HDL-C and triglycerides (TG) were determined by using PTS PANELS Lipid Panel test strips. Concurrently, TC, HDL-C, LDL-C and TG were measured by automated enzymatic procedure on a MODULAR ANALYTICS SWA and reagents from Roche Diagnostics. Results: TC measurements by both techniques did not differ significantly (paired t test): 189±42 mg/dl by the laboratory, 189±33 by the CardioCheck. TC measurement by CardioChek correlated vs laboratory determination (r = 0.79, p<0.0001) with a small y-intercept (-0.90). On the contrary, portable measurements systematically underestimated TG (122±99 mg/dl vs 141±96, p<0.0001) and HDL-C (39±14 vs 46±11, p<0.001). TG measurement by CardioChek correlated vs laboratory determination (r = 0.99, p<0.0001) but with a large y-intercept (-30.806). Calculated LDL-C by CardioChek (115±30 mg/dl) was similar to measured LDL-C by the laboratory (107±60 mg/dl, NS). Conclusions: The values of total cholesterol and LDL cholesterol from the portable lipid analyzer may be used for screening patients with hypercholesterolemia, whereas portable measurements of triglycerides and HDL cholesterol were underestimated systematically.

CardioChek PA cholesterol-testing device compared to diagnostic laboratory method

GIAMPIETRO, OTTAVIO;MATTEUCCI, ELENA
2007

Abstract

Background and Aims: High blood cholesterol is a major modifiable risk factor for cardiovascular disease. Point-of-care lipid screening requires precise, accurate, and reliable instruments. The aim of this study was to evaluate the accuracy of the CardioChek PA analyzer in comparison with clinical diagnostic laboratory methods. Methods: In 50 diabetic patients, total cholesterol (TC) was measured by using PTS PANELS CHOL+GLU Test Panel test strips and venous blood drawn in EDTA; in additional 18 patients, TC, HDL-C and triglycerides (TG) were determined by using PTS PANELS Lipid Panel test strips. Concurrently, TC, HDL-C, LDL-C and TG were measured by automated enzymatic procedure on a MODULAR ANALYTICS SWA and reagents from Roche Diagnostics. Results: TC measurements by both techniques did not differ significantly (paired t test): 189±42 mg/dl by the laboratory, 189±33 by the CardioCheck. TC measurement by CardioChek correlated vs laboratory determination (r = 0.79, p<0.0001) with a small y-intercept (-0.90). On the contrary, portable measurements systematically underestimated TG (122±99 mg/dl vs 141±96, p<0.0001) and HDL-C (39±14 vs 46±11, p<0.001). TG measurement by CardioChek correlated vs laboratory determination (r = 0.99, p<0.0001) but with a large y-intercept (-30.806). Calculated LDL-C by CardioChek (115±30 mg/dl) was similar to measured LDL-C by the laboratory (107±60 mg/dl, NS). Conclusions: The values of total cholesterol and LDL cholesterol from the portable lipid analyzer may be used for screening patients with hypercholesterolemia, whereas portable measurements of triglycerides and HDL cholesterol were underestimated systematically.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/199151
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