Six diterpenes, including two new natural products, were isolated from the seeds of Cephalotaxus harringtonia. The new metabolites were characterised as 8β-hydroxy-9(11),13-abietadien-12-one and 5,6-didehydroferruginol, while the known compounds were identified as ferruginol, sugiol, 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one, and abieta-8,11,13-trien-7β-ol. These compounds were studied in vitro for their antimicrobial activity against clinically isolated bacteria and Candida strains. Ferruginol and 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one showed antimicrobial activity against Gram-positive bacteria. None of the six diterpenes was active against the Gram-negative organisms and yeasts tested.

Antimicrobial Diterpenes from the Seeds of Cephalotaxus harringtonia var. drupacea

BRACA, ALESSANDRA;MORELLI, IVANO;
2003

Abstract

Six diterpenes, including two new natural products, were isolated from the seeds of Cephalotaxus harringtonia. The new metabolites were characterised as 8β-hydroxy-9(11),13-abietadien-12-one and 5,6-didehydroferruginol, while the known compounds were identified as ferruginol, sugiol, 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one, and abieta-8,11,13-trien-7β-ol. These compounds were studied in vitro for their antimicrobial activity against clinically isolated bacteria and Candida strains. Ferruginol and 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one showed antimicrobial activity against Gram-positive bacteria. None of the six diterpenes was active against the Gram-negative organisms and yeasts tested.
Politi, M.; Braca, Alessandra; DE TOMMASI, N.; Morelli, Ivano; Manunta, A.; Battinelli, L.; Mazzanti, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/199273
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