Synthesis and benzodiazepine receptor binding activity of 2, 9-disubstituted quinolino[2', 3'-5, 4](3-pyrazolino)[3, 2-b]purin-4-ones

Elsayed, Oa; Habib, Ns; Aboulenein, Hy; Costa, Barbara; Lucacchini, Antonio; Martini, Claudia

doi:10.1002/1521-4184(200205)335:5<207::AID-ARDP207>3.0.CO;2-5

2,9-Disubstituted quinolino[2',3'-5,4](3-pyrazolino)pyrimidin-2-ones and purin-4-ones were synthesized and their benzodiazepine receptor activity was evaluated for their ability to displace [H-3]R015-1788 from its specific binding in bovine brain membranes. Compound 5c caused 83+/-8% inhibition in [3H]R015-1788 specific benzodiazepine receptor binding followed by compounds 5f, 5h, and 5i while other analogs were inactive at 10 muM concentration.

Autori interni:	ELSAYED OA HABIB NS ABOULENEIN HY COSTA, BARBARA LUCACCHINI, ANTONIO MARTINI, CLAUDIA mostra contributor esterni nascondi contributor esterni
Autori:	ELSAYED OA; HABIB NS; ABOULENEIN HY; COSTA B; LUCACCHINI A; MARTINI C
Titolo:	Synthesis and benzodiazepine receptor binding activity of 2, 9-disubstituted quinolino[2', 3'-5, 4](3-pyrazolino)[3, 2-b]purin-4-ones
Anno del prodotto:	2002
Digital Object Identifier (DOI):	10.1002/1521-4184(200205)335:5<207::AID-ARDP207>3.0.CO;2-5
Appare nelle tipologie:	1.1 Articolo in rivista

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Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11568/199558

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