2,9-Disubstituted quinolino[2',3'-5,4](3-pyrazolino)pyrimidin-2-ones and purin-4-ones were synthesized and their benzodiazepine receptor activity was evaluated for their ability to displace [H-3]R015-1788 from its specific binding in bovine brain membranes. Compound 5c caused 83+/-8% inhibition in [3H]R015-1788 specific benzodiazepine receptor binding followed by compounds 5f, 5h, and 5i while other analogs were inactive at 10 muM concentration.
|Autori:||ELSAYED OA; HABIB NS; ABOULENEIN HY; COSTA B; LUCACCHINI A; MARTINI C|
|Titolo:||Synthesis and benzodiazepine receptor binding activity of 2, 9-disubstituted quinolino[2', 3'-5, 4](3-pyrazolino)[3, 2-b]purin-4-ones|
|Anno del prodotto:||2002|
|Digital Object Identifier (DOI):||10.1002/1521-4184(200205)335:5<207::AID-ARDP207>3.0.CO;2-5|
|Appare nelle tipologie:||1.1 Articolo in rivista|