Expression of two MDR genes, BCRP and MDR1, was evaluated by real-time PCR technique in 51 AML patients. Fifty-six percent expressed the BCRP gene, with the 48.2% showing intermediate levels. Eighty-eight percent expressed the MDR1, with 23.8% of cases at high expression. A significant correlation between BCRP and MDR1 values was found by regression analysis. Either levels of BCRP or MDR1 did not correlate with clinical characteristics of patients at diagnosis.
|Autori:||GALIMBERTI S; GUERRINI F; PALUMBO GA; CONSOLI U; FAZZI R; MORABITO F; SANTINI V; PETRINI M|
|Titolo:||Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patients|
|Anno del prodotto:||2004|
|Appare nelle tipologie:||1.1 Articolo in rivista|