OBJECTIVE: The aim of this case report was to analyze clinical and histological features of a central odontogenic fibroma followed up for 6 years after surgical excision. METHODS: A 26-year old Caucasian female was referred, reporting a painless gingival swelling in the buccal area of the maxillary right canine. There were no other symptoms and no recent history of pain. Her medical history was non-contributory. Radiographic evaluation showed the presence of a radiolucent area with well-defined margins. The lesion was surgically removed and histologically analysed. RESULTS: Histologic analysis showed a cellular fibroblastic tissue characterized by interwoven bundles of collagen densely packed and absence of odontogenic epithelium. The surgical site was monitored for 6 years after surgery with no signs of recurrence. CONCLUSION: The central odontogenic fibroma here reported displayed a prominent quantity of collagen and absence of odontogenic epithelium. The surgically removed lesion had a favourable prognosis and no recurrence for the 6 year follow-up period.
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