OBJECTIVE: To evaluate local carotid stiffness (CS) and intima-medial thickness (C-IMT) in hypertensive patients with different cardiovascular risk profile, using a new user-friendly ultrasound-based system, previously validated vs. RF-based echotracking device. METHODS: We investigated a population with different cardiovascular risk: 45 healthy normotensives (NT), 90 non-diabetic hypertensives (HT), and 48 patients with hypertension and type-2 diabetes (DM). Framingham risk factor score (FRS) was calculated. PWV was assessed by applanation tonometry. The relative stroke change in diameter (DeltaD) and C-IMT were measured on carotid scans. Distensibility coefficient (DC) was calculated as DeltaA/(A*DeltaP), where A=diastolic lumen area, DeltaA=stroke change in lumen area, and DeltaP=carotid pulse pressure. CS (m/s) was calculated as (rho*DC)-1/2 (rho=blood density). RESULTS: CS, C-IMT, PWV were significantly increased in HT and DM vs. NT. C-IMT and PWV were significantly higher in DM than HT. DeltaD and DC were significantly lower in HT and DM vs. NT. FRS ≥10% group showed increased carotid diameter, C-IMT and CS than the FRS <10%. FRS was (p<0.001) correlated with CS (r=0.35); DeltaD (r=-0.36), DC (r=0.35), C-IMT (r=0.48), PWV (r=0.38). CS correlated (p<0.05) with PWV in the entire population (r=0.37), in the NT (r=0.35), in the HT and DM (r=0.20). PWV (r=0.50) and CS (r=0.33) were correlated with age. Determinants of aortic and carotid stiffness were identified by multivariate stepwise analysis. CONCLUSIONS: The proposed B-mode ultrasound-based system is a reliable and user-friendly method that could serve to investigate the predictive value of CS for cardiovascular events in future large clinical studies.
|Autori:||Giannarelli C; Bianchini E; Bruno RM; Magagna A; Landini L; Faita F; Gemignani V; Penno G; Taddei S; Ghiadoni L|
|Titolo:||Local carotid stiffness and intima-media thickness assessment by a novel ultrasound-based system in essential hypertension|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.1016/j.atherosclerosis.2012.05.027|
|Appare nelle tipologie:||1.1 Articolo in rivista|