We investigated the possible existence of endogenous compounds acting on benzodiazepine central receptors in the serum of patients with panic attacks or depression. Our results show the presence of a substance which inhibits the 3H-flunitrazepam binding specifically in the samples taken from the patients' groups, and which is not present in normal controls, in the range of concentrations used. This compound has a molecular weight below 1,000 daltons, is heat-stable, and resistant to proteolytic degradation. The demonstration of this inhibitor opens new perspectives in the study of the biochemistry of anxiety.

A 3H-flunitrazepam binding inhibitor is present in psychiatric patients' sera.

MARAZZITI, DONATELLA;PIETRINI, PIETRO;MARTINI, CLAUDIA;GIANNACCINI, GINO;PERUGI, GIULIO;PLACIDI, GIANFRANCO;CASSANO, GIOVANNI BATTISTA;LUCACCHINI, ANTONIO
1987-01-01

Abstract

We investigated the possible existence of endogenous compounds acting on benzodiazepine central receptors in the serum of patients with panic attacks or depression. Our results show the presence of a substance which inhibits the 3H-flunitrazepam binding specifically in the samples taken from the patients' groups, and which is not present in normal controls, in the range of concentrations used. This compound has a molecular weight below 1,000 daltons, is heat-stable, and resistant to proteolytic degradation. The demonstration of this inhibitor opens new perspectives in the study of the biochemistry of anxiety.
1987
Marazziti, Donatella; Pietrini, Pietro; Martini, Claudia; Giannaccini, Gino; Perugi, Giulio; Placidi, Gianfranco; Cassano, GIOVANNI BATTISTA; Lucacchini, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/201617
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