Multidrug resistance is frequently found in patients affected by hematological malignancies and has been related to a poor prognosis of acute leukemia. In the present paper we report results concerning the activity of idarubicin, an anthracycline derivative, on the leukemic P388 and P388 doxorubicin-resistant cell lines. The results clearly show that idarubicin inhibits DNA synthesis in the resistant cell line more actively than doxorubicin.

Idarubicin is active on MDR cells: evaluation of DNA synthesis inhibition on P388 cell lines

PETRINI, MARIO;MATTII, LETIZIA;SABBATINI, ANTONIETTA RAFFAELLA MARIA;
1993

Abstract

Multidrug resistance is frequently found in patients affected by hematological malignancies and has been related to a poor prognosis of acute leukemia. In the present paper we report results concerning the activity of idarubicin, an anthracycline derivative, on the leukemic P388 and P388 doxorubicin-resistant cell lines. The results clearly show that idarubicin inhibits DNA synthesis in the resistant cell line more actively than doxorubicin.
Petrini, Mario; Mattii, Letizia; Valentini, P; Sabbatini, ANTONIETTA RAFFAELLA MARIA; Grassi, B; Grandi, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/201635
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