EnglishMultidrug resistance is frequently found in patients affected by hematological malignancies and has been related to a poor prognosis of acute leukemia. In the present paper we report results concerning the activity of idarubicin, an anthracycline derivative, on the leukemic P388 and P388 doxorubicin-resistant cell lines. The results clearly show that idarubicin inhibits DNA synthesis in the resistant cell line more actively than doxorubicin.
| Autori: | |
| Autori: | Petrini M; Mattii L; Valentini P; Sabbatini A; Grassi B; Grandi M. |
| Titolo: | Idarubicin is active on MDR cells: evaluation of DNA synthesis inhibition on P388 cell lines |
| Anno del prodotto: | 1993 |
| Digital Object Identifier (DOI): | 10.1007/BF01715052 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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