A severe atrophy of the cerebellum was observed in a 7-monthold male Italian hound with a history of progressive ataxia and head tremor from the age of 3 months. On clinical examination, signs included severe hypermetric gait, head tremors and proprioception deficits in all limbs. At necropsy, a pronounced symmetrical reduction in size of the cerebellum was the only gross lesion observed. Histological examination of the cerebellum revealed marked thinning of the granular and molecular layers with almost complete loss of granule cells. Purkinje cells had normal morphology and distribution. These findings differ from those of previous reports of cerebellar cortical abiotrophy in dogs, which were mainly characterized by prominent Purkinje cell degeneration and loss.

Cerebellar granuloprival degeneration in an Italian Hound

CANTILE, CARLO;SALVADORI, CLAUDIA;MODENATO, MARIO;ARISPICI, MARIO;
2002

Abstract

A severe atrophy of the cerebellum was observed in a 7-monthold male Italian hound with a history of progressive ataxia and head tremor from the age of 3 months. On clinical examination, signs included severe hypermetric gait, head tremors and proprioception deficits in all limbs. At necropsy, a pronounced symmetrical reduction in size of the cerebellum was the only gross lesion observed. Histological examination of the cerebellum revealed marked thinning of the granular and molecular layers with almost complete loss of granule cells. Purkinje cells had normal morphology and distribution. These findings differ from those of previous reports of cerebellar cortical abiotrophy in dogs, which were mainly characterized by prominent Purkinje cell degeneration and loss.
Cantile, Carlo; Salvadori, Claudia; Modenato, Mario; Arispici, Mario; Fatzer, R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/201786
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