The racemic forms of three new carbon-carbon double bond locked analogs of strobilurins I (R = Ph, 2-naphthyl, 6-methoxy-2-naphthyl) which are characterized by a 2-arylcyclopropane ring cis-substituted at C-1 by the Me (E)-3-methoxypropenoate unit, have been synthesized according to a strategy which involves the palladium-catalyzed synthesis of Me (E)-3-methoxy-2-[(Z)-2-(aryl)ethenyl]propenoates and their stereospecific cyclopropanation. Rsn I were screened for anticancer activity.
Autori interni: | |
Autori: | A. CARPITA; A. RIBECAI; ROSSI R; P. STABILE |
Titolo: | Synthesis of the racemic forms of carbon-carbon double bond locked analogues of strobilurins which are characterized by a 2-arylcyclopropane ring cis-substituted at C-1 by the methyl (E)-3-methoxypropenoate unit |
Anno del prodotto: | 2002 |
Digital Object Identifier (DOI): | 10.1016/S0040-4020(02)00334-4 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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