The aim of this study is to assess renal effects 10 days after preoperative administration of carprofen in cats. Twenty cats (14 females and 6 males) of weight 3.2±0.7 kg, age 8±2 months, scheduled for ovariectomy and orchiectomy surgery were enrolled for a randomized double-blind study. The day of surgery (D0) one group (10 cats) received carprofen 4 mg kg-1 (group M-carp) and the other (10 cats) placebo with NaCl (group M-pl), given subcutaneous preoperatively. Animals were anesthetized with medetomidine 50 mcg kg-1 and ketamine 5 mg Kg-1 and maintained with ketamine (1-2 mg Kg-1)-diazepam (0.2-0.3 mg Kg-1). Heart rate (HR), respiratory rate (RR) and systolic arterial pressure (SAP) were monitored. Renal function was assessed with renal ultrasound, serum biochemical analysis, urinalysis, glomerular filtration rate (GFR) and urine protein pattern with sodium dodecyl-sulphate-polyacrylamide gel electrophoresis (SDS-page). Ten days after surgery (D10) all cats were anesthetized as D0 but without carprofen/placebo and all analysis repeated. Statistical analysis employed paired Student T-test and ANOVA with Tukey’s post hoc test. Duration of D0 anesthesia was 54±12 minutes for M-carp group and 51±7 minutes for M-pl. SAP was significantly higher (p<0.05) in group M-pl (164.8±18 mmHg) compared to M-carp (149.8±12 mmHg). Renal ultrasound did not reveal differences between D0 and D10 in both groups. Hematological and urine values did not differ significantly between the groups (see table). GFR in M-pl group mildly decreased at D10 compared to D0; this GFR reduction was not detected in M-carp group. SDS-page evaluation of urinary protein gave the same results. The preoperative administration of carprofen at a dosage of 4 mg/kg subcutaneously did not produce significant adverse effects on renal function, as measured 10 days after administration, in healthy cats anesthetized with medetomidine-ketamine and diazepam. The study was funded by Pfizer Animal Health Italy
Renal effects of preoperative carprofen during medetomidine-ketamine anaesthesia in cats: a clinical study
MELANIE, PIERRE;BRIGANTI, ANGELA;
2007-01-01
Abstract
The aim of this study is to assess renal effects 10 days after preoperative administration of carprofen in cats. Twenty cats (14 females and 6 males) of weight 3.2±0.7 kg, age 8±2 months, scheduled for ovariectomy and orchiectomy surgery were enrolled for a randomized double-blind study. The day of surgery (D0) one group (10 cats) received carprofen 4 mg kg-1 (group M-carp) and the other (10 cats) placebo with NaCl (group M-pl), given subcutaneous preoperatively. Animals were anesthetized with medetomidine 50 mcg kg-1 and ketamine 5 mg Kg-1 and maintained with ketamine (1-2 mg Kg-1)-diazepam (0.2-0.3 mg Kg-1). Heart rate (HR), respiratory rate (RR) and systolic arterial pressure (SAP) were monitored. Renal function was assessed with renal ultrasound, serum biochemical analysis, urinalysis, glomerular filtration rate (GFR) and urine protein pattern with sodium dodecyl-sulphate-polyacrylamide gel electrophoresis (SDS-page). Ten days after surgery (D10) all cats were anesthetized as D0 but without carprofen/placebo and all analysis repeated. Statistical analysis employed paired Student T-test and ANOVA with Tukey’s post hoc test. Duration of D0 anesthesia was 54±12 minutes for M-carp group and 51±7 minutes for M-pl. SAP was significantly higher (p<0.05) in group M-pl (164.8±18 mmHg) compared to M-carp (149.8±12 mmHg). Renal ultrasound did not reveal differences between D0 and D10 in both groups. Hematological and urine values did not differ significantly between the groups (see table). GFR in M-pl group mildly decreased at D10 compared to D0; this GFR reduction was not detected in M-carp group. SDS-page evaluation of urinary protein gave the same results. The preoperative administration of carprofen at a dosage of 4 mg/kg subcutaneously did not produce significant adverse effects on renal function, as measured 10 days after administration, in healthy cats anesthetized with medetomidine-ketamine and diazepam. The study was funded by Pfizer Animal Health ItalyI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
