In a patient suffering from histologically-documented immuno-mediated chronic active hepatitis, intravenous immunoglobulin (IVIG) treatment was initiated as an obligatory alternative therapy because of femur head aseptic necrosis which had followed long-term therapy with steroids. The first cycle of IVIG was followed by remission of most symptoms, normalization of liver enzymes, disappearance of circulating immunecomplexes (CIC), and a negative lupus band test. Improvement in the patient's condition was demonstrated, in liver histology, by the disappearance of peri-portal mononuclear cells infiltrates, while immunohistochemistry showed the disappearance of the intracellular IgG deposits.
|Autori:||Carmassi, Franco; Morale, M; Puccetti, R; Pistelli, F; Palla, R; Bevilacqua, Generoso; Viacava, P; Antonelli, Alessandro; Mariani, Giuliano|
|Titolo:||Efficacy of intravenous immunoglobulin therapy in a case of autoimmune-mediated chronic active hepatitis|
|Anno del prodotto:||1992|
|Appare nelle tipologie:||1.1 Articolo in rivista|