Objectives: To estimate the risk of HIV-1 transmission through breast-milk in children born to infected mothers, and to determine the relationship between duration of breast-feeding and risk. Design and methods: The study population included 168 breast-fed and 793 bottle-fed children born to seropositive mothers. All subjects were enrolled and followed-up in the Italian Register for HIV Infection in Children; HIV serostatus was defined in all children. Multivariate analysis was performed using a logistic regression model. Independent variables included biological factors (duration of breast-feeding, gestational age, clinical condition of mother at delivery, mode of delivery, birth-weight and sex). Year of birth and age when HIV infection was diagnosed were also considered in the analysis attempting to control for possible selection biases. Results: Breast-feeding increased the risk of HIV-1 transmission. The estimated adjusted odds ratio for 1 day of breast- versus bottle-feeding was 1.19 (95% confidence interval, 1.10-1.28). The infection odds ratio of breast- versus bottle-feeding increased with the natural logarithm of the duration of practice. Conclusions: These results are the first to provide an appraisal of the additional risk of HIV-1 transmission associated with a seropositive mother breast-feeding her child. Biological significance of this route of transmission was supported by demonstration of a relationship between duration of breast-feeding and risk of HIV-1 transmission.
|Autori:||DE MARTINO; M; TOVO; PA; TOZZI; AE; PEZZOTTI; P; GALLI; L; LIVADIOTTI; S; CASELLI; D; MASSIRONI; E; RUGA; E; FIOREDDA; F; PLEBANI; A; GABIANO; C; ZUCCOTTI; Other partecipants in the Italian Register for HIV Infection in Children GV; Conte; A; Rizzi; M; Mazzoni; PL; Ibba; P; Ferraris; G; Benaglia; G; Stegagno; M; Masi; M; Dallacasa; P; Duse; M; Rossi; G; Sciotto; A; Barbanera; M; De Mattai; D; Zaniboni; MG; Bezzi; T; Campelli; A; Ciccimarra; F; Bassanetti; F; Consolini r; et al|
|Titolo:||HIV-1 TRANSMISSION THROUGH BREAST-MILK - APPRAISAL OF RISK ACCORDING TO DURATION OF FEEDING|
|Anno del prodotto:||1992|
|Digital Object Identifier (DOI):||10.1097/00002030-199209000-00013|
|Appare nelle tipologie:||1.1 Articolo in rivista|