Title compounds were synthesised from the protected beta-D-ribofuranosyl-1-azide, the sodium salt of malononitrile and the suitable aroyl nitrile. The deblocked 8-azaadenosines had shown good activity as inhibitors of adenosine deaminase (ADA) and a non-substrate behaviour toward the hydrolytic deamination promoted by the enzyme.
Synthesis and ADA Inhibitory Activity of New 2-Aryl-8-Azaadenosines
GIORGI, IRENE;
1992-01-01
Abstract
Title compounds were synthesised from the protected beta-D-ribofuranosyl-1-azide, the sodium salt of malononitrile and the suitable aroyl nitrile. The deblocked 8-azaadenosines had shown good activity as inhibitors of adenosine deaminase (ADA) and a non-substrate behaviour toward the hydrolytic deamination promoted by the enzyme.File in questo prodotto:
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