the aim of this experimental study was to evaluate the attention modulating actions on the polysynaptic component of blink reflex responses and especially of the R3 component in patients suffering from Parkinson's Disease (PD). To this end, a non-task warning paradigm was adopted. Methods: attention processing was evaluated by means of a non-task paradigm in 55 patients suffering from PD. Subjects were presented with a visual 'warning' prostimulus and the blink reflex (BR) analyzed with special regard for any modulation of its polysynaptic components (R2-R3). Results: The mean amplitude of the post-warning R3 component (PW-R3c) of 'de novo' PD patients was 62% of the corresponding component following unannounced stimuli, a figure which differs significantly from both treated PD patients (18.9%) and control subjects (15.4%). Do novo patients subsequently started on L-dopa therapy exhibited a more pronounced inhibition of the R3 component after warning stimulus, as the PW-R3c percentage decreased. Inversely, treated patients whose therapy was withheld showed decreased inhibition of this component. Regarding R2, the mean PW-R2c in the do novo patients differed slightly from that of the treated patients (P < 0.05), but not from that of the control subjects. Such a finding may be attributable to a specific effects on the excitability of the polysynaptic responses. Conclusions: Attention disorders in PD have been well documented by means of this kind of non-task warning paradigm, which appears to probe the modulation of the BR R3 component, even if the interpretation of this R3 changes suggesting a specific alteration of attention processing must be put forward extremely carefully, because something similar, but less evident, appears also for R2.
|Autori:||L. GABRIELLI; P. NOCITA; C. PASETTI; U. BONUCCELLI; G. DELL'AGNELLO; M.C. CARBONCINI; ROSSI B|
|Titolo:||Impaired attention modulation of the blink reflex R3 component in Parkinson's disease: a non task warning paradigm study|
|Anno del prodotto:||2002|
|Digital Object Identifier (DOI):||10.1016/S0167-8760(01)00195-7|
|Appare nelle tipologie:||1.1 Articolo in rivista|