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EnglishContinuing our research aimed at obtaining new Compounds with high affinity and selectivity toward alpha(1)-AR, a new series of arylpiperazine derivatives was designed, synthesized, and biologically tested. The new Compounds 1-17 are characterized by a phenylphthalazin-1(2H)-one fragment connected through an alkyl chain to an arylpiperazine residue. The pharmacological profile of these compounds was evaluated for their affinity and selectivity toward alpha(1)-AR, alpha(2)-AR and toward 5HT(1A) serotoninergic receptor. A discussion on the structure-activity relationship (SAR) of these compounds is also reported.
| Autori interni: | ||
| Autori: | Strappaghetti G; Brodi C; Giannaccini G; Betti L | |
| Titolo: | New 4-(4-methyl-phenyl)phthalazin-1(2H)-one derivatives and their effects on alpha(1)-receptors | |
| Anno del prodotto: | 2006 | |
| Digital Object Identifier (DOI): | 10.1016/j.bmcl.2006.02.068 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/203159
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