Treatment of (hetero)aryl halides with 2-(1-alkynyl)benzoic acids or (Z)-2-en-4-ynoic acids in the presence of K2CO3 and a catalytic amount of Pd(PPh3)(4) provides reaction mixtures in which stereodefined 3-[(1,1-unsymetrically disubstituted)methylidene]isobenzofuran-1(3H)-ones and stereodefined 5-[(1,1-unsymmetrically disubstituted)methylidene]furan-2(5H)-ones respectively, are the major products. (C) 2000 Elsevier Science Ltd. All rights reserved.

Palladium-catalyzed synthesis of stereodefined 3-[(1,1-unsymmetrically disubstituted)methylidene]isobenzofuran-1(3H)-ones and stereodefined 5-[(1,1-unsymmetrically disubstituted)methylidene]furan-2(5H)-ones

ROSSI, RENZO;BELLINA, FABIO;
2000

Abstract

Treatment of (hetero)aryl halides with 2-(1-alkynyl)benzoic acids or (Z)-2-en-4-ynoic acids in the presence of K2CO3 and a catalytic amount of Pd(PPh3)(4) provides reaction mixtures in which stereodefined 3-[(1,1-unsymetrically disubstituted)methylidene]isobenzofuran-1(3H)-ones and stereodefined 5-[(1,1-unsymmetrically disubstituted)methylidene]furan-2(5H)-ones respectively, are the major products. (C) 2000 Elsevier Science Ltd. All rights reserved.
Rossi, Renzo; Bellina, Fabio; Biagetti, M; Catanese, A; Mannina, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/203401
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