The cavernous sinuses are the most peculiar feature of the nasal angioarchitecture, due to their ability to retain a large quantity of blood in reply to a variety of topical and systemic stimuli. Recently, nitric oxide (NO) has seemed to be crucially involved in the nasal vascular regulation. The distribution of NO-synthase (NOS), the enzyme that catalyzes the formation of NO, was studied in the endothelium of nasal blood vessels by the ultracytochemical detection of reduced nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) enzymic activity. The endothelium of the cavernous sinuses appeared strongly positive, whereas the endothelium of arterioles was occasionally labeled. The endothelial cells of capillaries and venules were found to be NADPH-d negative. The strong enzymic activity observed in the cavernous sinuses suggests a major role of NO in the capacitance vessels compared to the resistance vessels. The hypothesis of a reciprocal inhibition between the NOS enzymic pathways present in the respiratory epithelium and in the endothelium of cavernous sinuses is put forward. The nasal disorders characterized by anomalous vasomotility and vascular permeability could be caused in part by the irregular control of these complex interactions.
|Autori:||Ruffoli, Riccardo; Fattori, Bruno; Soldani, Paola; Giambelluca, Maria; Giannessi, Francesco|
|Titolo:||Ultrastructural localization of NADPH-Diaphorase activity in the endothelial cells of human nasal respiratory mucosa.|
|Anno del prodotto:||1999|
|Digital Object Identifier (DOI):||10.2500/105065899781389849|
|Appare nelle tipologie:||1.1 Articolo in rivista|