OBJECTIVE: To analyze aspects of a series of papillary thyroid carcinomas and evaluate the prognostic features specific to different age classes. STUDY DESIGN: Retrospective study. SUBJECTS AND METHODS: From 2000 to 2005, 2709 patients underwent a total thyroidectomy for papillary thyroid carcinoma in our department. Patients were divided into three groups: <18 years (G1), 19 to 45 years (G2), and >46 years (G3). Histologic and clinical features were statistically evaluated. RESULTS: Tumor size was larger in G1 when compared with both G2 and G3 (P < 0.0001). Infiltration of the thyroid capsule and node metastases were higher in G1 than both G2 and G3 (P < 0.0001). The Tall-cell variant was more represented in G2 and G3. CONCLUSION: In the pediatric population, papillary carcinoma is a more aggressive disease. Because pediatric cancers have a better prognosis than their adult counterparts, this does not influence patient outcome. Age can then be considered the most important factor in determining prognosis. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.
|Autori:||MICCOLI P; MINUTO MN; UGOLINI C; PANICUCCI E; MASSI M; BERTI P; BASOLO F|
|Titolo:||Papillary thyroid cancer: Pathological parameters as prognostic factors in different classes of age|
|Anno del prodotto:||2008|
|Digital Object Identifier (DOI):||10.1016/j.otohns.2007.10.034|
|Appare nelle tipologie:||1.1 Articolo in rivista|