In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.

Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation

DANTI, SERENA;D'ALESSANDRO, DELFO;MOSCATO, STEFANIA;BERRETTINI, STEFANO;PETRINI, MARIO;
2010

Abstract

In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.
Ciofani, G; Danti, Serena; D'Alessandro, Delfo; Ricotti, L; Moscato, Stefania; Bertoni, S; Falqui, A; Berrettini, Stefano; Petrini, Mario; Mattoli, V; Menciassi, A.
File in questo prodotto:
File Dimensione Formato  
30/84493626922450933729508145500937554134

solo utenti autorizzati

Tipologia: Versione finale editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 6.59 MB
Formato Unknown
6.59 MB Unknown   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/203555
Citazioni
  • ???jsp.display-item.citation.pmc??? 34
  • Scopus 153
  • ???jsp.display-item.citation.isi??? 143
social impact