A 72-year-old man, receiving 8 mg daptomycin/kg body weight/day for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, was diagnosed with MRSA/vancomycin-resistant Enterococcus faecium (VRE) cholecystitis (daptomycin MIC values, 1 and 2 mg/liter, respectively). After the fifth drug dose, the bile concentration of daptomycin was 66 mg/liter 5 min after drug administration, with the biliary concentration/MIC values higher than 30 for both bacterial strains. Therefore, daptomycin achieved therapeutic levels in bile, hence suggesting a role for the drug in the treatment of MRSA/VRE cholecystitis.
Autori interni: | |
Autori: | Tascini, Carlo; DI PAOLO, Antonello; Polillo, Marialuisa; Ferrari, Mauro; Lambelet, Paola; Danesi, Romano; Menichetti, Francesco |
Titolo: | Case report of a successful treatment of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and MRSA/vancomycin-resistant Enterococcus faecium cholecystitis by daptomycin |
Anno del prodotto: | 2011 |
Digital Object Identifier (DOI): | 10.1128/AAC.01774-10 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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