The in vitro activities of human beta-defensin 3 (hBD-3) alone or combined with lysozyme, metronidazole, amoxicillin, and chlorhexidine were investigated with the oral bacteria Streptococcus mutans, Streptococcus sanguinis, Streptococcus sobrinus, Lactobacillus acidophilus, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis. hBD-3 showed bactericidal activity against all of the bacterial species tested. The bactericidal effect was enhanced when the peptide was used in combination with the antimicrobial agents mentioned above.

Activity of human beta-defensin 3 alone or combined with other antimicrobial agents against oral bacteria

MAISETTA, GIUSEPPANTONIO;BATONI, GIOVANNA;ESIN, SEMIH;BOTTAI, DARIA;FLORIO, WALTER;GIUCA, MARIA RITA;GABRIELE, MARIO;CAMPA, MARIO
2003

Abstract

The in vitro activities of human beta-defensin 3 (hBD-3) alone or combined with lysozyme, metronidazole, amoxicillin, and chlorhexidine were investigated with the oral bacteria Streptococcus mutans, Streptococcus sanguinis, Streptococcus sobrinus, Lactobacillus acidophilus, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis. hBD-3 showed bactericidal activity against all of the bacterial species tested. The bactericidal effect was enhanced when the peptide was used in combination with the antimicrobial agents mentioned above.
Maisetta, Giuseppantonio; Batoni, Giovanna; Esin, Semih; Luperini, F.; Pardini, M.; Bottai, Daria; Florio, Walter; Giuca, MARIA RITA; Gabriele, Mario; Campa, Mario
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/203845
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