(5R)-5-Alkyl-5,6-dihydroindolizines 3a-c having the same high enantiomeric excess (>92%) as the corresponding starting olefins (3R)-3-(pyrrol-1-yl)alk-1-enes 1a-c were obtained via a highly regioselective and stereospecific domino hydroformylation/cyclodehydration reaction sequence. The reasons for this configurational stability were also analyzed in the light of the general accepted rhodium catalyzed hydroformylation mechanism.
(5R)-5-alkyl-5,6-dihydroindolizines via stereospecific domino hydroformylation/cyclodehydration of (3R)-3-(pyrrol-1-yl)alk-1-enes
MANDOLI, ALESSANDRO;LAZZARONI, RAFFAELLO
2004
Abstract
(5R)-5-Alkyl-5,6-dihydroindolizines 3a-c having the same high enantiomeric excess (>92%) as the corresponding starting olefins (3R)-3-(pyrrol-1-yl)alk-1-enes 1a-c were obtained via a highly regioselective and stereospecific domino hydroformylation/cyclodehydration reaction sequence. The reasons for this configurational stability were also analyzed in the light of the general accepted rhodium catalyzed hydroformylation mechanism.File in questo prodotto:
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