(5R)-5-Alkyl-5,6-dihydroindolizines 3a-c having the same high enantiomeric excess (>92%) as the corresponding starting olefins (3R)-3-(pyrrol-1-yl)alk-1-enes 1a-c were obtained via a highly regioselective and stereospecific domino hydroformylation/cyclodehydration reaction sequence. The reasons for this configurational stability were also analyzed in the light of the general accepted rhodium catalyzed hydroformylation mechanism.
Autori interni: | |
Autori: | SETTAMBOLO R; GUAZZELLI G; MANDOLI A; LAZZARONI R |
Titolo: | (5R)-5-alkyl-5,6-dihydroindolizines via stereospecific domino hydroformylation/cyclodehydration of (3R)-3-(pyrrol-1-yl)alk-1-enes |
Anno del prodotto: | 2004 |
Digital Object Identifier (DOI): | 10.1016/j.tetasy.2004.04.045 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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