The disposition and tissue distribution of enrofloxacin and of its main metabolite ciprofloxacin were investigated in ducks after oral or intramuscular administration of a single dose of 10 mg/kg enrofloxacin.. Plasma and tissue concentrations were determined by a HPLC method. The peak concentrations of enrofloxacin after intramuscular administration (1.67 mu g/ml at 0.9 h) were higher than after an oral dose (0.99 mu g/ml at 1.38 h). The relative bioavailability of enrofloxacin after administration directly into the crop was 68%, while the metabolic conversion of enrofloxacin to ciprofloxacin was quite low (< 10%) with both routes of administration. High tissue concentrations and high tissue:plasma concentration ratios were demonstrated for enrofloxacin and ciprofloxacin 24 h after treatment. it was concluded that a dose of 10 mg/kg per day provides serum and tissue concentrations sufficiently high to be effective in the control of many infectious diseases of ducks.
|Autori interni:||INTORRE, LUIGI|
|Autori:||Intorre L; Mengozzi G; Bertini S; Bagliacca M; Luchetti E; Soldani G|
|Titolo:||The plasma kinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in the Muscovy duck|
|Anno del prodotto:||1997|
|Digital Object Identifier (DOI):||10.1023/A:1005847110638|
|Appare nelle tipologie:||1.1 Articolo in rivista|