OBJECTIVE:Aim of the study was to investigate the presence of underlying abnormalities affecting the hypothalamus-pituitary-gonadal axis in 13 normal weight eumenhorreic bulimics as expressed by a different gonadotropin response to gonadotropin releasing hormone (GnRH), comparing patients with (n = 6) and without (n = 7) purging behaviours to controls (n = 5). METHOD:Subjects were administered an intravenous GnRH infusion for four hours, with an additional bolus at first and third hour. RESULTS:Non-purging bulimics showed a significantly reduced luteinizing hormone (LH) response to GnRH compared to controls; purging bulimics, following the second bolus, demonstrated a statistically reduced peak, in comparison to both controls and non-purging bulimics.DISCUSSION:even in the absence of overt menstrual disturbances, an altered LH secretion elicited by pulsatile stimulation of endogenous GnRH was found, with a more severe impairment in purging than in non-purging bulimics, possibly related to their greater psychopathological and physical burden.
|Autori:||RAMACCIOTTI C; GUIDI L; BONDI E; COLI E; DELL'OSSO L; PISTOIA S; PUCCI E|
|Titolo:||Differential dynamic responses of luteinizing hormone to gonadotropin releasing hormone in patients affected by bulimia nervosa-purging versus non-purging type|
|Anno del prodotto:||1997|
|Appare nelle tipologie:||1.1 Articolo in rivista|