Synthesis and assay of title compounds are reported. The results can support our hypothesis about the possibility that molecules characterized by great flexibility, as the title 2-phenyl-4,5,6-triaminopyrimidines, can better interact with the receptor sites compared with rigid molecules as 2,6,9-trisubstituted 8-azaadenines. Relatively low activity shown by pyrimidine derivatives demonstrated the importance of the bicyclic aromatic system in 8-azaadenines and adenines to give a favourable interaction between a hexogenous molecule and the A(?)1 adenosine receptors.
|Autori:||Biagi G; Giorgi I; Livi O; Scartoni V; Lucacchini A|
|Titolo:||Synthesis of 4,6-disubstituted- and 4,5,6-trisubstituted-2-phenyl-pyrimidines and their affinity towards A(1) adenosine receptors|
|Anno del prodotto:||1997|
|Appare nelle tipologie:||1.1 Articolo in rivista|