The synthesis, the benzodiazepine binding activity and the ''in vitro'' biological effect of some 1,2,4-triazolo[1,5-a]quinoxalines, 3-aza-analogues of some previously reported pyrazolo[1,5-a]quinoxalines, are described. Molecular modelling is used to define the structural requirements of the benzodiazepine recognition site which influence the affinity and different efficacy of these rigid ligands.

TRICYCLIC HETEROAROMATIC SYSTEMS 1,2,4-TRIAZOLO[1,5-A]QUINOXALINES - SYNTHESIS AND BENZODIAZEPINE RECEPTOR ACTIVITY

MARTINI, CLAUDIA;GIUSTI, LAURA;LUCACCHINI, ANTONIO
1993

Abstract

The synthesis, the benzodiazepine binding activity and the ''in vitro'' biological effect of some 1,2,4-triazolo[1,5-a]quinoxalines, 3-aza-analogues of some previously reported pyrazolo[1,5-a]quinoxalines, are described. Molecular modelling is used to define the structural requirements of the benzodiazepine recognition site which influence the affinity and different efficacy of these rigid ligands.
Catarzi, D; Cecchi, L; Colotta, V; Melani, F; Filacchioni, G; Martini, Claudia; Giusti, Laura; Lucacchini, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/204221
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