The synthesis, the benzodiazepine binding activity and the ''in vitro'' biological effect of some 1,2,4-triazolo[1,5-a]quinoxalines, 3-aza-analogues of some previously reported pyrazolo[1,5-a]quinoxalines, are described. Molecular modelling is used to define the structural requirements of the benzodiazepine recognition site which influence the affinity and different efficacy of these rigid ligands.
TRICYCLIC HETEROAROMATIC SYSTEMS 1,2,4-TRIAZOLO[1,5-A]QUINOXALINES - SYNTHESIS AND BENZODIAZEPINE RECEPTOR ACTIVITY
MARTINI, CLAUDIA;GIUSTI, LAURA;LUCACCHINI, ANTONIO
1993-01-01
Abstract
The synthesis, the benzodiazepine binding activity and the ''in vitro'' biological effect of some 1,2,4-triazolo[1,5-a]quinoxalines, 3-aza-analogues of some previously reported pyrazolo[1,5-a]quinoxalines, are described. Molecular modelling is used to define the structural requirements of the benzodiazepine recognition site which influence the affinity and different efficacy of these rigid ligands.File in questo prodotto:
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