This paper reports the continuation of the studies on the 4-aminosubstituted 1,2,3-triazole[4,5-d]pyridazine derivatives which had shown binding affinity towards adenosine receptors. Biological results confirmed the greater activity of a benzyl substituent in the 1 position and the receptorial stereoselectivity related to the higher and more selective A1 affinity of the 4-D(+)-α-methylbenzylamino enantiomer 1b. The 4-phenylhydrazino substituent has shown an interesting binding activity about equipotent towards A1 and A2 receptorial sites. A surprisingly elevated A1 affinity (Ki = 7 nM), 440 fold higher than A2 affinity, is presented by compound 1d, bearing a m-toluidino substituent.
Autori interni: | |
Autori: | Biagi G; Giorgi I; Livi O; Scartoni V; Velo S; Martini C; Senatore G; Barili PL.; Lucacchini A; |
Titolo: | 1,2,3-Triazole[4,5-d]pyridazines IV. Preparation and Adenosine Receptor Binding of New 4-and /or 7-Aminoderivatives |
Anno del prodotto: | 1995 |
Appare nelle tipologie: | 1.1 Articolo in rivista |