Background: Previous results suggested that blood pressure (BP) response to exercise was significantly correlated with HbA1c levels in healthy normotensive non-diabetic control subjects. Present investigation evaluated the biologic determinants of arterial BP during one-year follow-up in patients with type 2 diabetes (T2D). Materials and methods: Cardiovascular risk factors were assessed at baseline, 1, 3, 6, 9 and 12 months in 20 T2D (age 60 ± 5 year). Were measured: body mass index (BMI), waist to hip ratio (WHR), mean BP, fasting plasma glucose (FPG), HbA1c, plasma LDL cholesterol, folate and total homocysteine (tHcy), urinary albumin excretion (UAE). Dietary habits were estimated at each visit by administering a 2-day 24-h dietary recall (24 HDR). Results: BMI was 31 ± 5 kg/m2, WHR 0Æ97 ± 0Æ06, mean BP 98 ± 10 mmHg, FPG 159 ± 42 mg/dL, HbA1c 7Æ4 ± 1Æ2%, LDL 118 ± 31 mg/dL, folati 8Æ9 ± 6Æ6 ng/mL, tHcy 11Æ5 ± 3Æ4 lmol/ L. UAE ranged from 0 to 2957 lg/min (median 15Æ8). Multivariate regression analysis of longitudinal data found the following independent variables to be associated with MBP (|r| = 0Æ54, P < 0Æ0001): HbA1c (t-value 5Æ24), folati (-2Æ84), and LDL (2Æ21). Estimated daily intake of folic acid was 286 ± 129 lg/day significantly lower than Recommended Dietary Allowance. Conclusions: This study confirms in T2D previous observations in healthy people. There is a significant positive correlation between protein glycosylation and arterial BP. Additional influential factors are plasma folate and LDL cholesterol. These findings strengthen the need for maintaining a strict metabolic control (glycosylation of matrix proteins affect artery compliance) and promoting an adequate dietary intake of folate.

One-year follow-up of biologic correlates for arterial blood pressure in type 2 diabetes

MATTEUCCI, ELENA;GIAMPIETRO, OTTAVIO
2009

Abstract

Background: Previous results suggested that blood pressure (BP) response to exercise was significantly correlated with HbA1c levels in healthy normotensive non-diabetic control subjects. Present investigation evaluated the biologic determinants of arterial BP during one-year follow-up in patients with type 2 diabetes (T2D). Materials and methods: Cardiovascular risk factors were assessed at baseline, 1, 3, 6, 9 and 12 months in 20 T2D (age 60 ± 5 year). Were measured: body mass index (BMI), waist to hip ratio (WHR), mean BP, fasting plasma glucose (FPG), HbA1c, plasma LDL cholesterol, folate and total homocysteine (tHcy), urinary albumin excretion (UAE). Dietary habits were estimated at each visit by administering a 2-day 24-h dietary recall (24 HDR). Results: BMI was 31 ± 5 kg/m2, WHR 0Æ97 ± 0Æ06, mean BP 98 ± 10 mmHg, FPG 159 ± 42 mg/dL, HbA1c 7Æ4 ± 1Æ2%, LDL 118 ± 31 mg/dL, folati 8Æ9 ± 6Æ6 ng/mL, tHcy 11Æ5 ± 3Æ4 lmol/ L. UAE ranged from 0 to 2957 lg/min (median 15Æ8). Multivariate regression analysis of longitudinal data found the following independent variables to be associated with MBP (|r| = 0Æ54, P < 0Æ0001): HbA1c (t-value 5Æ24), folati (-2Æ84), and LDL (2Æ21). Estimated daily intake of folic acid was 286 ± 129 lg/day significantly lower than Recommended Dietary Allowance. Conclusions: This study confirms in T2D previous observations in healthy people. There is a significant positive correlation between protein glycosylation and arterial BP. Additional influential factors are plasma folate and LDL cholesterol. These findings strengthen the need for maintaining a strict metabolic control (glycosylation of matrix proteins affect artery compliance) and promoting an adequate dietary intake of folate.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/204580
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