Bacterial pyelonephritis was induced in mice by direct microinoculation of Pseudomonas aeruginosa in the kidney. In the acute phase of P. aeruginosa pyelonephritis, a state of cell-mediated immunity impairment, evaluated both in vitro as lymphocyte reactivity to concanavalin A and in vivo as host versus graft reaction has been observed. Furthermore, delayed-type hypersensitivity to specific bacterial antigen has been detected only when the kidney infection was subsiding, i.e., 3 weeks after bacteria inoculation. When investigating the mechanism of such T-cell impairment, we were unable to transfer the immunodepression, suggesting that suppressor cells are not involved in vivo. The role of P. aeruginosa inhibition of cell-mediated immunity in the pyelonephritic host is discussed.
|Autori:||COLIZZI V; CAMPA M; GARZELLI C; TOCA L; BEVILACQUA G; FALCONE G|
|Titolo:||IMPAIRMENT OF CELL-MEDIATED-IMMUNITY IN PSEUDOMONAS-AERUGINOSA PYELONEPHRITIS - LACK OF SUPPRESSOR-CELL ACTIVITY IN VIVO|
|Anno del prodotto:||1982|
|Digital Object Identifier (DOI):||10.1007/BF02123620|
|Appare nelle tipologie:||1.1 Articolo in rivista|