Several title compounds were assayed to determine their relative affinity towards the adenosine receptors. Selectivity ratios (SR) showed a prevalent A(I) affinity. The comparison with the selectivity ratios of the corresponding 9-benzyl-8-azaadenines and the comparison between the affinity constant values (K-I) for each receptor of the two series, were performed. The results led us to conclude that A(I) receptors are characterized by more different arrangements which regard especially to 9-benzyl-8-azaadenines.

2-Aryl-8-Azaadenosines: Structure-Activity Relationships in the Binding with A1 and A2 Receptors. A Comparison with the Corresponding 9-Benzyl-8-Azaadenines

GIORGI, IRENE;LUCACCHINI, ANTONIO;MARTINI, CLAUDIA;
1994

Abstract

Several title compounds were assayed to determine their relative affinity towards the adenosine receptors. Selectivity ratios (SR) showed a prevalent A(I) affinity. The comparison with the selectivity ratios of the corresponding 9-benzyl-8-azaadenines and the comparison between the affinity constant values (K-I) for each receptor of the two series, were performed. The results led us to conclude that A(I) receptors are characterized by more different arrangements which regard especially to 9-benzyl-8-azaadenines.
Biagi, G; Giorgi, Irene; Livi, O; Scartoni, V; Lucacchini, Antonio; Martini, Claudia; Tacchi, P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/204843
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