(3R)-3-(Pyrrol-1-yl)but-1-ene 4a, (3R)-4-methyl-3-(pyrrol-1-yl)pent-1-ene 4b, (3R)-3-(pyrrol-1-yl)hex-1-ene 4c in high enantiomeric excess (>92%) were prepared starting from d-α-amino acids. The crucial steps in the synthesis, reduction (DIBAH) of the corresponding pyrrolylesters to the corresponding pyrrolylaldehydes followed by Wittig olefination proceeded without compromising the stereochemical integrity.

A new class of optically active pyrrole derivatives. (3R)-3-(pyrrol-1-yl)alk-1-enes from D-a-aminoacids

MANDOLI, ALESSANDRO;
2003

Abstract

(3R)-3-(Pyrrol-1-yl)but-1-ene 4a, (3R)-4-methyl-3-(pyrrol-1-yl)pent-1-ene 4b, (3R)-3-(pyrrol-1-yl)hex-1-ene 4c in high enantiomeric excess (>92%) were prepared starting from d-α-amino acids. The crucial steps in the synthesis, reduction (DIBAH) of the corresponding pyrrolylesters to the corresponding pyrrolylaldehydes followed by Wittig olefination proceeded without compromising the stereochemical integrity.
R., Settambolo; G., Guazzelli; L., Mengali; Mandoli, Alessandro; Lazzaroni, Raffaello
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/204976
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