Objective A paleopathological study was carried out on the she skeletal remains of Cardinal Carlo de'Medici (1595-1666), son of the Grand Duke Ferdinando I (1549-1609) and Cristina from. Lorraine (1565-1636), to investigate the articular pathology described in the archival sources. Methods The skeletal remains of Carlo, buried in the Basilica of San Lorenzo in Florence, have been exhumed and submitted to macroscopic and radiological examination. Results The skeleton of Carlo revealed a concentration of different severe pathologies. Ankylosis of the cervical column, associated with other facial and spine anomalies suggests a diagnosis of congenital disease: the Klippel-Feil syndrome. In addition, the cervical segment presents the results of the tuberculosis (Pott's disease)from which the Cardinal suffered in his infancy. The post-cranial skeleton shows an ankylosing disease, mainly symmetrical and extremely severe,, involving the large as well as small articulations, and characterized by massive joint fusion, that totally disabled the Cardinal in his last Years of life. Conclusions The final diagnosis suggests all advanced, ankylosing stage of rheumatoid arthritis.
Rheumatoid arthritis, Klippel-Feil syndrome and Pott's disease in Cardinal Carlo de'Medici (1595-1666)
GIUFFRA, VALENTINA;Fornaciari A;CARAMELLA, DAVIDE;FORNACIARI, GINO
2009-01-01
Abstract
Objective A paleopathological study was carried out on the she skeletal remains of Cardinal Carlo de'Medici (1595-1666), son of the Grand Duke Ferdinando I (1549-1609) and Cristina from. Lorraine (1565-1636), to investigate the articular pathology described in the archival sources. Methods The skeletal remains of Carlo, buried in the Basilica of San Lorenzo in Florence, have been exhumed and submitted to macroscopic and radiological examination. Results The skeleton of Carlo revealed a concentration of different severe pathologies. Ankylosis of the cervical column, associated with other facial and spine anomalies suggests a diagnosis of congenital disease: the Klippel-Feil syndrome. In addition, the cervical segment presents the results of the tuberculosis (Pott's disease)from which the Cardinal suffered in his infancy. The post-cranial skeleton shows an ankylosing disease, mainly symmetrical and extremely severe,, involving the large as well as small articulations, and characterized by massive joint fusion, that totally disabled the Cardinal in his last Years of life. Conclusions The final diagnosis suggests all advanced, ankylosing stage of rheumatoid arthritis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
