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EnglishThe presence of a [3H]muscimol binding site on the purified benzodiazepine receptor was demonstrated. The purified protein was apparently homogeneous as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (stained with silver), with a molecular weight of 60,000 +/- 3000. The benzodiazepine binding sites were characterized as being of the central type and the [3H]flunitrazepam binding was enhanced by GABA. This activation was antagonized by bicuculline. [3H]Muscimol specifically binds to the benzodiazepine receptor. The Scatchard plot indicates a Kd of 23 nM and the ratio [3H]flunitrazepam/[3H]muscimol is approximately unity.
| Autori interni: | |
| Autori: | Martini C; Rigacci T; Lucacchini A. |
| Titolo: | [H-3]MUSCIMOL BINDING-SITE ON PURIFIED BENZODIAZEPINE RECEPTOR |
| Anno del prodotto: | 1983 |
| Digital Object Identifier (DOI): | 10.1111/j.1471-4159.1983.tb09070.x |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/205099
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