We have developed three-dimensional electrospun microfibrous meshes of a novel star branched three-arm poly(epsilon-caprolactone) (*PCL) as potential scaffolds for tissue engineering applications. The processing conditions required to obtain uniform fibers were optimized by studying their influence on fiber morphology and size. Polymer molecular weight and solution feed rate influenced both the mesh microstructure and the tensile properties of the developed mats. Electrospun samples were also tested for their mechanical properties in wet conditions, showing higher yield strength and strain in comparison to that observed in dry conditions. Cell culture experiments employing MC3T3-E1 osteoblast like cells showed good cell viability adhesion and collagen production on the *PCL scaffolds.

Development of Electrospun Three-arm Star Poly(epsilon-caprolactone) Meshes for Tissue Engineering Applications

PUPPI, DARIO;PIRAS, ANNA MARIA;CHIELLINI, FEDERICA;CHIELLINI, EMO;
2010

Abstract

We have developed three-dimensional electrospun microfibrous meshes of a novel star branched three-arm poly(epsilon-caprolactone) (*PCL) as potential scaffolds for tissue engineering applications. The processing conditions required to obtain uniform fibers were optimized by studying their influence on fiber morphology and size. Polymer molecular weight and solution feed rate influenced both the mesh microstructure and the tensile properties of the developed mats. Electrospun samples were also tested for their mechanical properties in wet conditions, showing higher yield strength and strain in comparison to that observed in dry conditions. Cell culture experiments employing MC3T3-E1 osteoblast like cells showed good cell viability adhesion and collagen production on the *PCL scaffolds.
Puppi, Dario; Detta, N; Piras, ANNA MARIA; Chiellini, Federica; Chiellini, Emo; Clarke, D; Reilly, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/205499
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