The present invention provides compds. which are esters of a carbohydrate, constituted by a carbohydrate unit or a glycoside derived therefrom, having at least one alc. group esterified with a branched chain carboxylic acid and having the remaining alc. groups in part protected with a protector group, such as an isopropylidene group, and partly in the form of free hydroxyls. These carbohydrate esters being provided with a significant biol. activity as erythroid cellular differentiation inducers can be utilized for the prepn. of a medicament for the therapeutic treatment of beta-talaxemia or tumors. Thus, Me 6-O-pivaloyl-3,1-O-isopropylidene- beta-D-galactopyranoside was prepd. and tested in the human cell line K562 for inducing erythroid cellular differentiation (65%).
Preparation of glucidic esters of branched carboxylic acids capable of inducing erythroid cellular differentiation
CATELANI, GIORGIO;D'ANDREA, FELICIA;LIPUCCI DI PAOLA, MICHELE;
2000
Abstract
The present invention provides compds. which are esters of a carbohydrate, constituted by a carbohydrate unit or a glycoside derived therefrom, having at least one alc. group esterified with a branched chain carboxylic acid and having the remaining alc. groups in part protected with a protector group, such as an isopropylidene group, and partly in the form of free hydroxyls. These carbohydrate esters being provided with a significant biol. activity as erythroid cellular differentiation inducers can be utilized for the prepn. of a medicament for the therapeutic treatment of beta-talaxemia or tumors. Thus, Me 6-O-pivaloyl-3,1-O-isopropylidene- beta-D-galactopyranoside was prepd. and tested in the human cell line K562 for inducing erythroid cellular differentiation (65%).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
