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EnglishThe present invention provides compds. which are esters of a carbohydrate, constituted by a carbohydrate unit or a glycoside derived therefrom, having at least one alc. group esterified with a branched chain carboxylic acid and having the remaining alc. groups in part protected with a protector group, such as an isopropylidene group, and partly in the form of free hydroxyls. These carbohydrate esters being provided with a significant biol. activity as erythroid cellular differentiation inducers can be utilized for the prepn. of a medicament for the therapeutic treatment of beta-talaxemia or tumors. Thus, Me 6-O-pivaloyl-3,1-O-isopropylidene- beta-D-galactopyranoside was prepd. and tested in the human cell line K562 for inducing erythroid cellular differentiation (65%).
| Titolo: | Preparation of glucidic esters of branched carboxylic acids capable of inducing erythroid cellular differentiation | |
| Autori interni: | ||
| Anno di deposito: | 2000 | |
| Abstract: | The present invention provides compds. which are esters of a carbohydrate, constituted by a carbohydrate unit or a glycoside derived therefrom, having at least one alc. group esterified with a branched chain carboxylic acid and having the remaining alc. groups in part protected with a protector group, such as an isopropylidene group, and partly in the form of free hydroxyls. These carbohydrate esters being provided with a significant biol. activity as erythroid cellular differentiation inducers can be utilized for the prepn. of a medicament for the therapeutic treatment of beta-talaxemia or tumors. Thus, Me 6-O-pivaloyl-3,1-O-isopropylidene- beta-D-galactopyranoside was prepd. and tested in the human cell line K562 for inducing erythroid cellular differentiation (65%). | |
| Handle: | http://hdl.handle.net/11568/205544 | |
| Appare nelle tipologie: | 6.1 Brevetto |
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