CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishSeveral N-(indol-3-ylglyoxylyl)amino acid derivatives were synthesized and tested for their affinity for the benzodiazepine receptor in bovine cortical membranes. From these compounds, the N-[(5-chloro-, 5-bromo-, or 5-nitroindol-3-yl)glyoxylyl]glycine or -alanine esters were clearly the most potent, while the 5-methoxy analogues were considerably less active. Moreover, esters were more active than the corresponding acids. It is concluded that the affinity of these derivatives for the benzodiazepine receptor is profoundly dependent on amino acid molecular size, as well as the hydrophobic and electronic properties of the compounds.
| Autori interni: | ||
| Autori: | MARTINI C; GERVASIO T; LUCACCHINI A; DASETTIMO A; PRIMOFIORE G; MARINI AM | |
| Titolo: | SPECIFIC-INHIBITION OF BENZODIAZEPINE RECEPTOR-BINDING BY SOME N-(INDOL-3-YLGLYOXYLYL)AMINO ACID-DERIVATIVES | |
| Anno del prodotto: | 1985 | |
| Digital Object Identifier (DOI): | 10.1021/jm00382a022 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
Copyright © 2022