The synthesis of a series of 8-substituted 1,4-dihydro-1-aryl-3-methyl-[1]benzopyrano[3,4-d]pyrazol-4-ones (series 7) and 2,4-dihydro-2-aryl-3-methyl[1]benzopyranol[4,3-c]pyrazol-4-ones (series 8) is reported. Compounds of series 7 and 8 were tested for their ability to displace [H-3]flunitrazepam from bovine brain membranes and for their in vitro biological activity. The results allowed some conclusions to be drawn about the structural requirements of the benzodiazepine recognition site within this class of unusual ligands.
TRICYCLIC HETEROAROMATIC SYSTEMS - [1]BENZOPYRANO-PYRAZOL-4-ONES AS BENZODIAZEPINE RECEPTOR LIGANDS
MARTINI, CLAUDIA;LUCACCHINI, ANTONIO
1991
Abstract
The synthesis of a series of 8-substituted 1,4-dihydro-1-aryl-3-methyl-[1]benzopyrano[3,4-d]pyrazol-4-ones (series 7) and 2,4-dihydro-2-aryl-3-methyl[1]benzopyranol[4,3-c]pyrazol-4-ones (series 8) is reported. Compounds of series 7 and 8 were tested for their ability to displace [H-3]flunitrazepam from bovine brain membranes and for their in vitro biological activity. The results allowed some conclusions to be drawn about the structural requirements of the benzodiazepine recognition site within this class of unusual ligands.File in questo prodotto:
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