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EnglishTwo low-molecular-weight fractions of sodium hyaluronate (Na-HA), denominated Hyalastin® and Hyalectin®, were investigated as potential adjuvants for ophthalmic vehicles containing pilocarpine nitrate (PiN). Tests were also performed on an ionic complex (HA/PiB) prepared from hyaluronic acid (derived from Hyalastin®) and pilocarpine base. The performance of the vehicles under study was verified by miosis and ocular retention tests carried out on albino rabbits, against a series of reference vehicles, three of which contained a high-molecular-weight fraction of Na-HA (Healon®). The group of 14 reference and test preparations exhibited Newtonian or pseudoplastic flow characteristics and encompassed a wide range of apparent viscosities (1 to 1054 mPa s). The results indicate that the HA/PiB salt and the high-MW Na-HA can significantly increase the bioavailability of pilocarpine with respect to reference vehicles of comparable viscosity: an effect that can be reasonably attributed to muco-adhesive effects. Conversely, in the present rabbit tests, the low-MW fractions of Na-HA performed poorly as adjuvants for the PiN solutions.
| Autori interni: | ||
| Autori: | Saettone, M. F.; Chetoni, Patrizia; Torracca, M. T.; Giannaccini, B.; Monti, Daniela | |
| Titolo: | Evaluation of high- and low-molecular weight fractions of sodium hyaluronate and an ionic complex as adjuvants for topical ophthalmic vehicles containing pilocarpine | |
| Anno del prodotto: | 1991 | |
| Digital Object Identifier (DOI): | 10.1016/0378-5173(91)90051-O | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/205677
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